GREENVILLE -- An over-the-counter pharmaceuticals manufacturer will lay off 114 workers from its Piedmont factory by the end of October. It's the company's second round of layoffs in South Carolina in less than a year.

PL Developments, a New York-based company, gave notice about the layoffs on Aug. 29, according to the South Carolina WARN Act report.

Charles Cain, general counsel and chief administrative officer, said the layoffs were from the company restructuring its shifts to run its machines more efficiently.

"Like many pharmaceutical manufacturers in America right now, we have been impacted by an overall decline in consumer demand," Cain said. "We're still seeing strong demand for our core products, including the first aid products and the other products we make there at the Piedmont facility."

Since 2017, PL Developments has operated out of a 200,000 square-foot space off U.S. Route 25, near Interstate 185. It makes a host of over-the-counter products and first aid items that it sells to private label brands -- also known as generic or store brands -- and has factories in New York, California and Florida.

With the layoffs, PL Developments has eliminated weekend shifts and laid off those workers. But Cain said they are creating 50 more positions for a third shift that will be added on weekdays.

"The nature of these pharmaceutical manufacturing machines is that they're more efficient if they run 24 hours a day, because we don't have to stop and start and clean the machines in between shifts and things like that," Cain said.

All told, those 114 workers will still be laid off. If they are interested in the weekday third shift, they must reapply.

"If our demand picks up early next year, as we're anticipating, then we would have the opportunity to add more positions on a weekend shift again," Cain said.

The move comes on the heels of PL Developments closing its Clinton factory in January, laying off 113 workers. That decision was made as part of a "strategic realignment" of the company's liquids packaging department, which included significant investments in expanding capacity and improving productivity at two other locations: the Piedmont factory and a California factory.

When PL Developments opened its Piedmont factory, state leaders applauded the move. It promised to invest $45 million and create 450 new jobs. Along with the Piedmont location, the company has two distribution centers off Interstate 85 in Spartanburg County.