The New England Patriots (3-11) are an overwhelming underdog by two touchdowns as they aim to break a four-game skid in a matchup with the Buffalo Bills (11-3) on Sunday, December 22, 2024 at Highmark Stadium.

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Bills vs. Patriots game info Game day: Sunday, December 22, 2024 Game time: 4:25 p.m. ET TV channel: CBS Location: Orchard Park, New York Stadium: Highmark Stadium Live stream: Watch this game on Fubo Live stream: Watch this game on Paramount+ Watch Bills vs. Patriots on Fubo! Bills vs. Patriots odds & betting lines Spread favorite: Buffalo (-14) Moneyline: Buffalo (-1099), New England (+700) Total: 46.5 points More NFL odds Chiefs vs. Texans odds Ravens vs. Steelers odds Lions vs. Bears odds Colts vs. Titans odds Cardinals vs. Panthers odds Eagles vs. Commanders odds Bengals vs. Browns odds Rams vs. Jets odds Falcons vs. Giants odds Bills vs. Patriots recent matchups Buffalo is 4-1 versus New England over the last five matchups between the two teams. In those games versus the Patriots, the Bills have gone 3-2 against the spread, with those games eclipsing the total on four occasions. Buffalo has had the scoring advantage in those five matchups, totaling 158 points against New England's 100. Bills vs. Patriots betting insights Buffalo has a 9-5-0 record against the spread this season. In the 10 games this season the Bills have been moneyline favorites, they have put together a 9-1 record. New England has five wins against the spread in 14 opportunities this season (5-8-1). The Patriots are 3-11 in games they have been moneyline underdogs. Bills scoring insights The Bills score 35.0 points per game at home, higher than their 29.4 average away from home. On defense, Buffalo is giving up 17.7 points per game at home, better than its 25.5 average on the road. The Bills average fewer points in division games (28.0) than non-division games (32.8). Buffalo has conceded 19.0 points per game in the division, which is better than its mark against the rest of the league of 23.0. While the Bills' defense ranks second-worst in points allowed per game over the last three contests (32.0), they rank best offensively (41.7 points per game) over that stretch. Patriots scoring insights At home, the Patriots put up 20.3 points per game, better than their 14.5 average on the road. Defensively, New England's average at home, 25.7 points conceded, is worse than its average away, 22.9. On offense, the Patriots have scored 13.3 points per game in the division, below their average against the rest of the league of 18.5. New England is giving up 23.8 points per game in divisional contests, which is a little better than its 24.2 average in non-division games. Offensively in their previous three games, the Patriots are averaging 18.7 points, 20th in the league. On defense, they are giving up 29.7, which puts them 26th. Bills injury report Bills:

Dawuane Smoot: Full Participation in Practice (Wrist),

Curtis Samuel: Limited Participation in Practice (Ribs),

Taylor Rapp: Limited Participation in Practice (Neck),

Baylon Spector: Limited Participation in Practice (Calf),

Quintin Morris: Full Participation in Practice (Shoulder),

Dion Dawkins: Did Not Participate In Practice (NIR - Personal),

Matt Milano: Limited Participation in Practice (Biceps),

Dalton Kincaid: Full Participation in Practice (Knee),

Dorian Williams: Limited Participation in Practice (Elbow),

Damar Hamlin: Limited Participation in Practice (Ribs),

Rasul Douglas: Limited Participation in Practice (Knee),

Amari Cooper: Full Participation in Practice (Wrist),

DeWayne Carter: Full Participation in Practice (Wrist),

Spencer Brown: Full Participation in Practice (Neck)

Patriots injury report Patriots:

Deatrich Wise: Limited Participation in Practice (Foot),

Caedan Wallace: Limited Participation in Practice (Ankle),

Jahlani Tavai: Limited Participation in Practice (Groin),

Cole Strange: Limited Participation in Practice (Knee),

Vederian Lowe: Limited Participation in Practice (Shoulder),

Anfernee Jennings: Limited Participation in Practice (Knee),

Christian Gonzalez: Limited Participation in Practice (Shoulder),

Christian Barmore: Did Not Participate In Practice (NIR - Personal),

Javon Baker: Full Participation in Practice (Concussion),

Marcus Jones: Did Not Participate In Practice (Hip),

JaMycal Hasty: Did Not Participate In Practice (Ankle),

Kyle Dugger: Limited Participation in Practice (Ankle)

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