The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 900 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.

Institute of clinical medicine, Division of laboratory medicine, Department of immunology

We have a vacant Postdoctoral Fellowship in Systems and Molecular Immunology at The Jacobsen Laboratory which is situated at Department of Immunology, University of Oslo, Norway. The department is situated at Oslo University Hospital Rikshospitalet. Johanne Jacobsen is leader of the The Jacobsen Laboratory.

The three-year Postdoctoral Research Fellowship funded by the Norwegian Research Council. The position offers a competitive salary and access to the comprehensive Norwegian welfare system.

The lab is in Oslo, a vibrant, international city known for its high quality of life and stunning natural surroundings.

Project SummaryThe generation of durable, high-quality immunity against rapidly mutating pathogens is orchestrated within transient microanatomical structures known as Germinal Centers (GCs). Within these centers, B lymphocytes undergo intense selection to produce high-affinity antibodies and long-lived memory B cells. While follicular helper T (Tfh) cells are critical to this process, recent discoveries by our lab and others have revealed a more complex regulatory landscape. Other T cell subsets, including specialized CD4+ Foxp3+ T cells, dynamically modulate the GC response, creating a balance of "help" and "suppression" that controls the lifespan of the GC and the quality of the antibodies it produces. We are seeking an exceptional postdoctoral fellow to lead a project aimed at dissecting the molecular determinants of T cell heterogeneity and function within the GC, with a direct focus on their impact on B cell quality and antibody functionality.

The Jacobsen LaboratoryThe Jacobsen Laboratory at the University of Oslo (UiO) is a dynamic research group dedicated to understanding the T cell subsets that shape adaptive immunity. Situated at the Oslo University Hospital, we are part of a vibrant, translationally-oriented research environment with affiliations to the Precision Immunotherapy Alliance (PRIMA) Center of Excellence and the SPARK Norway innovation program. Our lab fosters an environment that provides the direct mentorship and networking opportunities essential for building a successful independent career.

A New Framework for T Cell Control of Antibody QualityOur central mission is to understand how the balance between productive help and necessary suppression is maintained within the GC to ensure the generation of high-affinity antibodies without triggering autoimmunity. To address this, our research program heavily focuses on studying T and B cell population dynamics through intravital 2-photon imaging and the role of secreted immune metabolites in these dynamics. The successful candidate will lead a project to develop novel sensors for intravital microscopy to study how these metabolites drive population dynamics. The Jacobsen laboratory has a dedicated 2-photon microscope for this purpose.

The candidate will have access to state-of-the-art technologies and extensive international collaborations, including:

We are seeking a highly motivated, creative, and intellectually fearless scientist to join our team.

Foundational Qualification requirements:

This interdisciplinary project requires a broad and deep skillset. We encourage applications from individuals who demonstrate excellence in at least one of the core domains below and a strong motivation to master the others.

Personal qualities:

Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications.

Read more about the benefits of working in the public sector at Employer Portal.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.

If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.

We hope that you will apply for the position.

More information about gender equality initiatives at UiO can be found here.

Your application should include:

Application with attachments must be submitted via our recruitment system Jobbnorge, click "Apply for the position".

When applying for the position, we ask you to retrieve your education results from Vitnemålsportalen.no. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language.

The best qualified candidates will invited for interviews.

Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we cannot, you will hear from us.

Please refer to Regulations for the Act on universities and colleges chapter 3 (Norwegian) and Guidelines concerning appointment to post doctoral and research posts at UiO.

The University of Oslo has a transfer agreement with all employees that is intended to secure the rights to all research results etc.