The 49ers and Seahawks both enter the 2025 NFL season looking a bit different and with hopes of mounting a bounce-back campaign. The division rivals will clash right off the bat this weekend, meeting in Seattle to see which NFC West team has more juice to kick off the year.

For the Seahawks, Geno Smith is out, but 2024 breakout quarterback Sam Darnold is in. Seattle has also said goodbye to D.K. Metcalf and Tyler Lockett, so Jaxon Smith-Njigba and Kenneth Walker III will be the primary skill-position weapons for new offensive coordinator Klint Kubiak. Many 'Hawks fans are ready for their squad to run, run, run.

For San Francisco, the departure of Deebo Samuel to Washington and the recovery of Brandon Aiyuk (knee) means Christian McCaffrey and George Kittle will be as vital to Brock Purdy's success as ever. Kyle Shanahan also has a couple shiny new toys to work with, though, in newly acquired back Brian Robinson Jr. and second-year wideout Ricky Pearsall (he's healthy this time around).

This should be a fantastic opening-week game, one that many NFC West fans will be tuning in to see. Here's where to watch the Seahawks vs. 49ers on Sunday, including TV channel, kickoff time, live-stream details and more.

The Seahawks vs. 49ers will air live on Fox, with Joe Davis (play-by-play), Greg Olsen (analyst) and Pam Oliver (sidelines) comprising the broadcast team.

Fans can also stream the game on Fubo, which currently offers a free trial.

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Seahawks vs. 49ers will kick off at 4:05 p.m. ET on Sunday, Sept. 7. The game will be played at Lumen Field in Seattle, WA.

You can listen to the Seahawks vs. 49ers on SiriusXM. Coverage will be available on channel 226 (Seattle's broadcast) and channel 381 (San Francisco's coverage).

New subscribers can enjoy SiriusXM for free for four months. Listen to live NBA, NFL, MLB and NHL games, plus NASCAR, college sports and more. Stay updated with all the news and get all the analysis on multiple sport-specific channels.

Here's the 2025 regular season schedule for Seattle.

Here's the 2025 regular season schedule for San Francisco.

Here's a complete look at the NFL schedule for Week 1 of the new season, with games spread out across four days.